Invention Grant
- Patent Title: Methods for producing members of specific binding pairs
- Patent Title (中): 生产特异性结合对成员的方法
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Application No.: US10803622Application Date: 2004-03-18
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Publication No.: US07732377B2Publication Date: 2010-06-08
- Inventor: John McCafferty , Anthony Richard Pope , Kevin Stuart Johnson , Henricus Renerus Jacobus Mattheus Hoogenboom , Andrew David Griffiths , Ronald Henry Jackson , Kaspar Philipp Holliger , James David Marks , Timothy Piers Clackson , David John Chiswell , Gregory Paul Winter , Timothy Peter Bonnert
- Applicant: John McCafferty , Anthony Richard Pope , Kevin Stuart Johnson , Henricus Renerus Jacobus Mattheus Hoogenboom , Andrew David Griffiths , Ronald Henry Jackson , Kaspar Philipp Holliger , James David Marks , Timothy Piers Clackson , David John Chiswell , Gregory Paul Winter , Timothy Peter Bonnert
- Applicant Address: GB Cambridgeshire GB Cambridge
- Assignee: Medical Research Council,MedImmune Limited
- Current Assignee: Medical Research Council,MedImmune Limited
- Current Assignee Address: GB Cambridgeshire GB Cambridge
- Agency: Howrey LLP
- Main IPC: C40B30/04
- IPC: C40B30/04 ; C12Q1/70 ; G01N33/53
Abstract:
A member of a specific binding pair (sbp) is identified by expressing DNA encoding a genetically diverse population of such sbp members in recombinant host cells in which the sbp members are displayed in functional form at the surface of a filamentous bacteriophage particle containing DNA encoding the sbp member, wherein the sbp member has a binding domain that consists of a dAb fragment. The displayed sbps may be selected by affinity with a complementary sbp member, and the DNA recovered from selected filamentous bacteriophage particles for expression of the selected sbp members.
Public/Granted literature
- US20040157214A1 Methods for producing members of specific binding pairs Public/Granted day:2004-08-12
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