Invention Grant
- Patent Title: Mitotic kinesin inhibitors
- Patent Title (中): 有丝分裂驱动蛋白抑制剂
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Application No.: US11660349Application Date: 2005-08-15
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Publication No.: US07732472B2Publication Date: 2010-06-08
- Inventor: Mark E. Fraley , Robert M. Garbaccio , George D. Hartman
- Applicant: Mark E. Fraley , Robert M. Garbaccio , George D. Hartman
- Applicant Address: US NJ Rahway US NJ Rahway
- Assignee: Merck & Co., Inc.,Merck Sharp & Dohme Corp.
- Current Assignee: Merck & Co., Inc.,Merck Sharp & Dohme Corp.
- Current Assignee Address: US NJ Rahway US NJ Rahway
- Agent Nicole M. Beeler; David A. Murhard
- International Application: PCT/US2005/028968 WO 20050815
- International Announcement: WO2006/023440 WO 20060302
- Main IPC: A61K31/42
- IPC: A61K31/42 ; C07D261/04
Abstract:
The present invention relates to dihydroisoxazoles that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention also relates to compositions which comprise these compounds, and methods of using them to treat cancer in mammals.
Public/Granted literature
- US20090005418A1 Mitotic Kinesin Inhibitors Public/Granted day:2009-01-01
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