Invention Grant
US07732618B2 Benzimidazole acetic acids exhibiting CRTH2 receptor antagonism and uses thereof
失效
显示CRTH2受体拮抗作用的苯并咪唑乙酸及其应用
- Patent Title: Benzimidazole acetic acids exhibiting CRTH2 receptor antagonism and uses thereof
- Patent Title (中): 显示CRTH2受体拮抗作用的苯并咪唑乙酸及其应用
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Application No.: US11230916Application Date: 2005-09-21
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Publication No.: US07732618B2Publication Date: 2010-06-08
- Inventor: Youssef L. Bennani , Lawrence Nathan Tumey , Elizabeth Ann Gleason , Michael Joseph Robarge
- Applicant: Youssef L. Bennani , Lawrence Nathan Tumey , Elizabeth Ann Gleason , Michael Joseph Robarge
- Applicant Address: US NJ Madison
- Assignee: Wyeth
- Current Assignee: Wyeth
- Current Assignee Address: US NJ Madison
- Agency: Finnegan, Henderson, Farabow, Garrett & Dunner, LLP
- Main IPC: A61K31/4184
- IPC: A61K31/4184 ; C07D235/04
Abstract:
The invention relates to benzimidazole acetic acid compounds which function as antagonists of the Chemoattractant Receptor-homologous molecule expressed on T-Helper type 2 cells (CRTH2) receptor. The invention also relates to the use of these compounds to inhibit the binding of prostaglandin D2 and its metabolites or certain thromboxane metabolites to the CRTH2 receptor and to treat disorders responsive to such inhibition.
Public/Granted literature
- US20060106081A1 Benzimidazole acetic acids exhibiting CRTH2 receptor antagonism and uses thereof Public/Granted day:2006-05-18
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