Invention Grant
- Patent Title: Naphthalene derivatives
- Patent Title (中): 萘衍生物
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Application No.: US12111989Application Date: 2008-04-30
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Publication No.: US07732622B2Publication Date: 2010-06-08
- Inventor: Miles Stuart Congreve , Gerard Martin Paul Giblin , Andrew McMurtrie Mason , Neil Derek Miller , Susan Roomans , Ann Louise Walker
- Applicant: Miles Stuart Congreve , Gerard Martin Paul Giblin , Andrew McMurtrie Mason , Neil Derek Miller , Susan Roomans , Ann Louise Walker
- Applicant Address: GB Greenford, Middlesex
- Assignee: Glaxo Group Limited
- Current Assignee: Glaxo Group Limited
- Current Assignee Address: GB Greenford, Middlesex
- Agent Bonnie L. Deppenbrock
- Priority: GB0103269.7 20010209
- Main IPC: C07D209/60
- IPC: C07D209/60 ; A61K31/40
Abstract:
A compound of formula (I) wherein R1 and R3 are the same or different and represent ═O, hydrogen, C1-6alkyl, C1-6dialkyl, ═CHC1-C5alkyl, ═S, or a 5- or 6-membered aryl; R4 to R9 are the same or different and represent hydrogen, C1-6alkoxy, OCF3, OCH2CF3, O-cyclopropyl, OCH2-cyclopropyl, C1-C6alkyl, S-alkyl, NR210 where R10 is hydrogen or C1-6alkyl, halogen, NO2, OH, CH2OC1-C6alkyl, CH2OH, or CF3; Q1 is hydrogen, C1-6alkyl, C1-6dialkyl, C1-6alkoxy, NHAc, NR210 where R10 is hydrogen or C1-6alkyl, difluoro, fluoro, ═O, or OH; Q2, Q3, Q4 and Q5 are the same or different and represent hydrogen, C1-6alkoxy, OCF3, OCH2CF3, O-cyclopropyl, OCH2-cyclopropyl, C1-C6alkyl, S-alkyl, NR210 where R10 is hydrogen or C1-6alkyl, halogen, NO2, OH, CH2OC1-C6alkyl, CH2OH, or a 5- or 6-membered aryl; with the proviso that the compounds [4-(1-oxo-1,3-dihydro-2H-benzo[f]isoindol-2-yl)phenyl]-2-propionic acid, sodium salt and [4-(4,9-diethoxy-1-oxo-1,3-dihydro-2H-benzo[f]isoindol-2-yl)phenyl]acetic acid are excluded; and pharmaceutically acceptable derivatives thereof.
Public/Granted literature
- US20080234358A1 NAPHTHALENE DERIVATIVES Public/Granted day:2008-09-25
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