A crossflow filtration system including at least one quick dry change crossflow filtration cartridge designed to rotatably interface with a manifold assembly. The quick dry change crossflow filtration cartridge can comprise a membrane element, for example an ultrafiltration membrane, microfiltration membrane, nanofiltration membrane or reverse osmosis membrane element enclosed within a housing. The quick dry change cartridge includes an inlet stream, a permeate stream and a concentrate stream. The manifold assembly includes three similar flow paths; an inlet stream, a permeate stream and a concentrate stream. When engaged, the cartridge and manifold assembly define continuous inlet flow paths, permeate flow paths and concentrate flow paths that connect across the interface. Thus, all of the connections to the water filtration system can be made onto the manifold, and the resulting connected system is compact and easy to connect.