Invention Grant
US07736875B2 Dipeptidyl peptidase I crystal structure and its uses
失效
大鼠catpedpin二肽基肽酶i（DPPI）晶体结构及其用途
- Patent Title: Dipeptidyl peptidase I crystal structure and its uses
- Patent Title (中): 大鼠catpedpin二肽基肽酶i（DPPI）晶体结构及其用途
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Application No.: US10363712Application Date: 2001-09-06
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Publication No.: US07736875B2Publication Date: 2010-06-15
- Inventor: Johan Gotthardt Olsen , Anders Kadziola , Søren Weis Dahl , Connie Lauritzen , Sine Larsen , John Pedersen , Dusan Turk , Marjetka Podobnik , Igor Stern
- Applicant: Johan Gotthardt Olsen , Anders Kadziola , Søren Weis Dahl , Connie Lauritzen , Sine Larsen , John Pedersen , Dusan Turk , Marjetka Podobnik , Igor Stern
- Applicant Address: DK Horsholm
- Assignee: Prozymex A/S
- Current Assignee: Prozymex A/S
- Current Assignee Address: DK Horsholm
- Agency: Frommer Lawrence & Haug LLP
- Agent Thomas J. Kowalski; Heather J. DiPietrantonio
- Priority: DK200001343 20000908
- International Application: PCT/DK01/00580 WO 20010906
- International Announcement: WO02/20804 WO 20020314
- Main IPC: C12N9/00
- IPC: C12N9/00 ; C12N9/14 ; C12N9/48 ; C12N9/50 ; C12N9/64
Abstract:
The present invention relates to structural studies of dipeptidyl peptidase I (DPPI) proteins, modified dipeptidyl peptidase I (DPPI) proteins and DPPI co-complexes. Included in the present invention is a crystal of a dipeptidyl peptidase I (DPPI) and corresponding structural information obtained by X-ray crystallography from rat and human DPPI. In addition, this invention relates to methods for using structure co-ordinates of DDPI, mutants hereof and co-complexes, to design compounds that bind to the active site or accessory binding sites of DPPI and to design improved inhibitors of DPPI or homologues of the enzyme.
Public/Granted literature
- US20040043469A1 Dipeptidyl peptidase i crystal structure and its uses Public/Granted day:2004-03-04
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