An automatic mouse charging system includes a charger plate and an automatically chargeable mouse. The charger plate includes an audio signal emitter for emitting an audio signal and a charging module for providing electric energy. The automatically chargeable mouse includes a mouse case, an electric energy storage element, multiple audio signal receivers, a driving mechanism, and a control unit. The audio signal receivers are used for receiving the audio signal. The control unit is used for discriminating one of the audio signal receivers that receives the strongest audio signal, thereby outputting a corresponding movement signal to the driving mechanism. The automatically chargeable mouse is moved toward the audio signal receiver that receives the strongest audio signal according to the movement signal.