Invention Grant
US07741071B2 Selective incorporation of 5-hydroxytryptophan into proteins in mammalian cells
有权
在哺乳动物细胞中将5-羟色氨酸选择性掺入蛋白质
- Patent Title: Selective incorporation of 5-hydroxytryptophan into proteins in mammalian cells
- Patent Title (中): 在哺乳动物细胞中将5-羟色氨酸选择性掺入蛋白质
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Application No.: US10580987Application Date: 2004-12-16
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Publication No.: US07741071B2Publication Date: 2010-06-22
- Inventor: Zhiwen Zhang , Lital Alfonta , Peter Schultz
- Applicant: Zhiwen Zhang , Lital Alfonta , Peter Schultz
- Applicant Address: US CA La Jolla
- Assignee: The Scripps Research Institute
- Current Assignee: The Scripps Research Institute
- Current Assignee Address: US CA La Jolla
- Agency: Quine Intellectual Property Law Group
- Agent Gary Baker
- International Application: PCT/US2004/042535 WO 20041216
- International Announcement: WO2006/001832 WO 20060105
- Main IPC: C12P21/06
- IPC: C12P21/06 ; C12N9/00 ; C12N15/74
Abstract:
This invention provides methods and compositions for incorporation of an unnatural amino acid into a peptide using an orthogonal aminoacyl tRNA synthetase/tRNA pair. In particular, an orthogonal pair is provided to incorporate 5-hydroxy-L-tryptophan in a position encoded by an opal mutation.
Public/Granted literature
- US20070111193A1 Selective incorporation of 5-hydroxytryptophan into proteins in mammalian cells Public/Granted day:2007-05-17
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