Invention Grant
- Patent Title: HIV integrase inhibitors
- Patent Title (中): HIV整合酶抑制剂
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Application No.: US11920032Application Date: 2006-05-05
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Publication No.: US07741315B2Publication Date: 2010-06-22
- Inventor: Joseph P. Vacca , John S. Wai , Linda S. Payne , Richard C. A. Isaacs , Richard Pracitto
- Applicant: Joseph P. Vacca , John S. Wai , Linda S. Payne , Richard C. A. Isaacs , Richard Pracitto
- Applicant Address: US NJ Rahway
- Assignee: Merck Sharp & Dohme Corp.
- Current Assignee: Merck Sharp & Dohme Corp.
- Current Assignee Address: US NJ Rahway
- Agent Kenneth R. Walton; Sheldon O. Heber
- International Application: PCT/US2006/017369 WO 20060505
- International Announcement: WO2006/121831 WO 20061116
- Main IPC: A01N43/00
- IPC: A01N43/00 ; A61K31/33 ; C07D491/00

Abstract:
Tricyclic compounds of Formula (I) are inhibitors of HIV integrase and inhibitors of HIV replication: wherein bond a, ring A, R1, R2 and R3 are defined herein. The compounds are useful for the prophylaxis or treatment of infection by HIV and the prophylaxis, treatment, or delay in the onset of AIDS. The compounds are employed against HIV infection and AIDS as compounds per se or in the form of pharmaceutically acceptable salts. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines.
Public/Granted literature
- US20090054399A1 HIV INTEGRASE INHIBITORS Public/Granted day:2009-02-26
Information query
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