Sealing devices such as packers comprise a metal foam material disposed on a surface. The metal foam material comprises an initial position comprising a plurality of pockets each having an initial volume and a compressed position in which at least one of the initial volumes of at least one of the plurality of pockets is reduced by compression of the metal foam material, thereby forming a seal. The seal may be formed directly between the metal foam material and a sealing surface such as an inner wall surface of a wellbore to divide an annulus of the wellbore. Alternatively, the seal may be at least partially formed between a sealing material disposed within one or more of the plurality of pockets that is extruded from at least one of the plurality of pockets during compression of the metal foam material.