Invention Grant
- Patent Title: Opioid agonist/antagonist combinations
- Patent Title (中): 阿片类激动剂/拮抗剂组合
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Application No.: US12220760Application Date: 2008-07-28
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Publication No.: US07749542B2Publication Date: 2010-07-06
- Inventor: Robert F. Kaiko , Robert D. Colucci
- Applicant: Robert F. Kaiko , Robert D. Colucci
- Applicant Address: US CT Stamford
- Assignee: Purdue Pharma LP
- Current Assignee: Purdue Pharma LP
- Current Assignee Address: US CT Stamford
- Agency: Davidson, Davidson & Kappel, LLC
- Main IPC: A61K9/14
- IPC: A61K9/14 ; A61K9/48

Abstract:
The invention is directed in part to oral dosage forms comprising a combination of an orally analgesically effective amount of an opioid agonist and an orally active opioid antagonist, the opioid antagonist being included in a ratio to the opioid agonist to provide a combination product which is analgesically effective when the combination is administered orally, but which is aversive in a physically dependent subject. Preferably, the amount of opioid antagonist included in the combination product provides at least a mildly negative, “aversive” experience in physically dependent addicts (e.g., precipitated abstinence syndrome).
Public/Granted literature
- US20080292694A1 Opioid agonist/antagonist combinations Public/Granted day:2008-11-27
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