Invention Grant
US07749542B2 Opioid agonist/antagonist combinations 有权
阿片类激动剂/拮抗剂组合

Opioid agonist/antagonist combinations
Abstract:
The invention is directed in part to oral dosage forms comprising a combination of an orally analgesically effective amount of an opioid agonist and an orally active opioid antagonist, the opioid antagonist being included in a ratio to the opioid agonist to provide a combination product which is analgesically effective when the combination is administered orally, but which is aversive in a physically dependent subject. Preferably, the amount of opioid antagonist included in the combination product provides at least a mildly negative, “aversive” experience in physically dependent addicts (e.g., precipitated abstinence syndrome).
Public/Granted literature
Information query
Patent Agency Ranking
0/0