Invention Grant
US07749958B2 Cystatin C as an antagonist of TGF-β and methods related thereto
有权
半胱氨酸蛋白酶抑制剂C作为TGF- 和相关的方法
- Patent Title: Cystatin C as an antagonist of TGF-β and methods related thereto
- Patent Title (中): 半胱氨酸蛋白酶抑制剂C作为TGF- 和相关的方法
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Application No.: US11852909Application Date: 2007-09-10
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Publication No.: US07749958B2Publication Date: 2010-07-06
- Inventor: William P. Schiemann
- Applicant: William P. Schiemann
- Applicant Address: US CO Denver
- Assignee: National Jewish Health
- Current Assignee: National Jewish Health
- Current Assignee Address: US CO Denver
- Agency: Sheridan Ross P.C.
- Main IPC: A01N37/18
- IPC: A01N37/18 ; A61K38/00 ; C07K5/00
Abstract:
Disclosed are Cystatin C (CysC) homologues, including CystC homologues that act as antagonists or inhibitors of transforming growth factor-β (TGF-β). Also disclosed are methods to identify CystC homologues that are antagonists or inhibitors of TGF-β and compositions and therapeutic methods using CystC and homologues thereof to regulate the activity of TGF-β, and TGF-β-mediated tumor malignancy and invasion and other TGF-β-mediated fibrotic or proliferative conditions and diseases.
Public/Granted literature
- US20090093401A1 CYSTATIN C AS AN ANTAGONIST OF TGF-BETA AND METHODS RELATED THERETO Public/Granted day:2009-04-09
Information query
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