Invention Grant
US07749965B2 Pharmaceutical composition comprising FGF18 and IL-1 antagonist and method of use
有权
包含FGF18和IL-1拮抗剂的药物组合物及其使用方法
- Patent Title: Pharmaceutical composition comprising FGF18 and IL-1 antagonist and method of use
- Patent Title (中): 包含FGF18和IL-1拮抗剂的药物组合物及其使用方法
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Application No.: US12103420Application Date: 2008-04-15
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Publication No.: US07749965B2Publication Date: 2010-07-06
- Inventor: Emma E. Moore , Jeff L. Ellsworth
- Applicant: Emma E. Moore , Jeff L. Ellsworth
- Applicant Address: US WA Seattle
- Assignee: ZymoGenetics, Inc.
- Current Assignee: ZymoGenetics, Inc.
- Current Assignee Address: US WA Seattle
- Agency: Woodcock Washburn LLP
- Main IPC: A61K38/20
- IPC: A61K38/20 ; A61K38/18 ; A61F2/00
Abstract:
FGF18 is known to stimulate the proliferation of chondrocytes, bone, and nervous tissue, resulting in repair of diseased tissue. When an IL-1 antagonist is administered in addition to FGF18, the effects on the IL-1 mediated disease and also, the effect on cartilage, bone, and nervous cell proliferation, are found to be greater than administration of FGF18 or the IL-1 antagonist alone. The present invention encompasses a pharmaceutical composition that combines FGF18 with IL-1 antagonist and methods of treating IL-1 mediated disease using this pharmaceutical composition.
Public/Granted literature
- US20080193501A1 PHARMACEUTICAL COMPOSITION COMPRISING FGF18 AND IL-1 ANTAGONIST AND METHOD OF USE Public/Granted day:2008-08-14
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