Invention Grant
US07749984B2 Computer-based model for identification and characterization of non-competitive inhibitors of nicotinic acetylcholine receptors and related ligand-gated ion channel receptors
失效
基于计算机的模型，用于鉴定和表征烟碱乙酰胆碱受体和相关配体门控离子通道受体的非竞争性抑制剂
- Patent Title: Computer-based model for identification and characterization of non-competitive inhibitors of nicotinic acetylcholine receptors and related ligand-gated ion channel receptors
- Patent Title (中): 基于计算机的模型，用于鉴定和表征烟碱乙酰胆碱受体和相关配体门控离子通道受体的非竞争性抑制剂
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Application No.: US10820809Application Date: 2004-04-09
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Publication No.: US07749984B2Publication Date: 2010-07-06
- Inventor: Irving W. Wainer , Krzysztof Jozwiak , Ruin Moaddel , Sarangan Ravichandran , Jack R. Collins
- Applicant: Irving W. Wainer , Krzysztof Jozwiak , Ruin Moaddel , Sarangan Ravichandran , Jack R. Collins
- Applicant Address: US DC Washington
- Assignee: The United States of America as represented by the Department of Health and Human Services
- Current Assignee: The United States of America as represented by the Department of Health and Human Services
- Current Assignee Address: US DC Washington
- Agency: Cantor Colburn LLP
- Main IPC: A61K314/85
- IPC: A61K314/85 ; C07C69/88
Abstract:
A computer readable medium holding data of a molecular model of a ligand-gated ion channel receptor and/or a computer system for modeling said receptor are provided by the instant invention. The molecular model can be used to design novel compounds having activity as non-competitive inhibitors of the ion channel. A preferred embodiment of the invention relates to nicotinic acetylcholine receptors. Compounds having activity as non-competitive inhibitors of ligand-gated ion channel receptors and methods for inhibiting the receptor and treating diseases or disorders mediated by function of the receptor are also disclosed.
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