Invention Grant
US07750025B2 Derivatives of N-phenyl (piperidine-2-yl) methyl benzamide, preparation method thereof and applications of same in therapeutics
失效
N-苯基(哌啶-2-基)甲基苯甲酰胺的衍生物及其制备方法及其在治疗中的应用
- Patent Title: Derivatives of N-phenyl (piperidine-2-yl) methyl benzamide, preparation method thereof and applications of same in therapeutics
- Patent Title (中): N-苯基(哌啶-2-基)甲基苯甲酰胺的衍生物及其制备方法及其在治疗中的应用
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Application No.: US11405169Application Date: 2006-04-17
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Publication No.: US07750025B2Publication Date: 2010-07-06
- Inventor: Gihad Dargazanli , Genevieve Estenne-Bouhtou , Pascale Magat
- Applicant: Gihad Dargazanli , Genevieve Estenne-Bouhtou , Pascale Magat
- Applicant Address: FR Paris
- Assignee: sanofi-aventis
- Current Assignee: sanofi-aventis
- Current Assignee Address: FR Paris
- Agent Kelly L. Bender
- Priority: FR0312140 20031017
- Main IPC: A61K31/445
- IPC: A61K31/445 ; C07D409/12

Abstract:
Compounds of formula (I) as defined herein: are useful for treating behavioral disorders associated with dementia, psychoses, in particular schizophrenia (deficient form and productive form) and acute or chronic extrapyramidal symptoms induced by neuroleptics; for the treatment of various forms of anxiety, panic attacks, phobias, and compulsive obsessive disorders; for treating various forms of depression, including psychotic depression; for treating disorders caused by alcohol abuse or weaning from alcohol, sexual behavior disorders, eating disorders and for treating migraine. Moreover, the compounds of the invention may be used for treating painful muscle contracture in rheumatology and in acute spinal pathology; for treating spastic contractures of medullary or cerebral origin; for the symptomatic treatment of acute and subacute pain of light to moderate intensity; for treating intense and/or chronic pain, neurogenic pain and intractable pain; for treating Parkinson's disease and Parkinson-like symptoms of neurodegenerative origin or induced by neuroleptics; for treating partial primary and secondary generalized epilepsy of simple or complex symptomology, mixed forms and other epileptic syndromes in addition to another antiepileptic treatment, or in monotherapy, for the treatment of sleep apnea, and for neuroprotection.
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