Invention Grant
US07750034B2 Aminocyclohexanes as dipeptidyl peptidase-IV inhibitors for the treatment or prevention of diabetes
有权
氨基环己烷作为二肽基肽酶-IV抑制剂用于治疗或预防糖尿病
- Patent Title: Aminocyclohexanes as dipeptidyl peptidase-IV inhibitors for the treatment or prevention of diabetes
- Patent Title (中): 氨基环己烷作为二肽基肽酶-IV抑制剂用于治疗或预防糖尿病
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Application No.: US12086362Application Date: 2007-01-19
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Publication No.: US07750034B2Publication Date: 2010-07-06
- Inventor: Tesfaye Biftu , Jason Cox , Danqing Feng , Anthony Mastracchio , Xiaoxia Qian , Ann E. Weber
- Applicant: Tesfaye Biftu , Jason Cox , Danqing Feng , Anthony Mastracchio , Xiaoxia Qian , Ann E. Weber
- Applicant Address: US NJ Rahway
- Assignee: Merck Sharp & Dohme Corp.
- Current Assignee: Merck Sharp & Dohme Corp.
- Current Assignee Address: US NJ Rahway
- Agent Philippe L. Durette; John C. Todaro
- International Application: PCT/US2007/001493 WO 20070119
- International Announcement: WO2007/087231 WO 20070802
- Main IPC: C07D513/04
- IPC: C07D513/04 ; C07D495/04 ; C07D493/04 ; C07D491/048 ; C07D487/04 ; A61K31/429 ; A61K31/424 ; A61K31/4188 ; A61K31/4162 ; A61K31/407
Abstract:
The present invention is directed to novel substituted aminocyclohexanes of structural formula (I) which are inhibitors of the dipeptidyl peptidase-IV enzyme and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly Type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.
Public/Granted literature
- US20090270467A1 Aminocyclohexanes as Dipeptidyl Peptidase-IV Inhibitors for the Treatment or Prevention of Diabetes Public/Granted day:2009-10-29
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