Invention Grant
- Patent Title: Molecular design of thermostable alcohol dehydrogenase for synthesis for chiral aromatic alcohols
- Patent Title (中): 用于合成手性芳族醇的热稳定醇脱氢酶的分子设计
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Application No.: US11881690Application Date: 2007-07-27
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Publication No.: US07750135B2Publication Date: 2010-07-06
- Inventor: J. Gregory Zeikus , Karla I. Ziegelmann-Fjeld , Claire Vieille
- Applicant: J. Gregory Zeikus , Karla I. Ziegelmann-Fjeld , Claire Vieille
- Applicant Address: US MI East Lansing
- Assignee: Board of Trustees of Michigan State University
- Current Assignee: Board of Trustees of Michigan State University
- Current Assignee Address: US MI East Lansing
- Agency: Medlen & Carroll, LLP
- Main IPC: C07H21/04
- IPC: C07H21/04 ; C12P21/06 ; C12N9/04
Abstract:
The present invention relates to compositions and methods utilizing thermostable and novel alcohol dehydrogenase enzymes for biosynthesizing chiral specific molecules for use as precursor molecules in synthesizing pharmaceutical compounds. Particularly, in preferred embodiments, the invention relates to directed engineering of an enzymatic catalytic site of an alcohol dehydrogenase enzyme gene for enhancing enantioselectivity for (S)-enantiomer substrate catalytic activity for providing aryl (S)-enantiomer products in stereomeric excess.
Public/Granted literature
- US20080220487A1 Molecular design of thermostable alcohol dehydrogenase for synthesis for chiral aromatic alcohols Public/Granted day:2008-09-11
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