Invention Grant
- Patent Title: Inhibitors of Akt activity
- Patent Title (中): Akt活性抑制剂
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Application No.: US11547113Application Date: 2005-04-05
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Publication No.: US07750151B2Publication Date: 2010-07-06
- Inventor: Mark T. Bilodeau , Chixu Chen , Nicholas D. P. Cosford , Brian W. Eastman , John C. Hartnett , Essa H. Hu , Peter J. Manley , Lou Anne Neilson , Lida R. Tehrani , Zhicai Wu
- Applicant: Mark T. Bilodeau , Chixu Chen , Nicholas D. P. Cosford , Brian W. Eastman , John C. Hartnett , Essa H. Hu , Peter J. Manley , Lou Anne Neilson , Lida R. Tehrani , Zhicai Wu
- Applicant Address: US NJ Rahway
- Assignee: Merck Sharp & Dohme Corp.
- Current Assignee: Merck Sharp & Dohme Corp.
- Current Assignee Address: US NJ Rahway
- Agent Matthew A. Leff; David A. Muthard
- International Application: PCT/US2005/011561 WO 20050405
- International Announcement: WO2005/100356 WO 20051027
- Main IPC: C07D471/04
- IPC: C07D471/04 ; C07D413/12 ; C07D521/00 ; C07D401/14 ; C07D487/08 ; A61P35/00
Abstract:
The present invention is directed to compounds which contain substituted napthyridines which inhibit the activity of Akt, a serine/threonine protein kinase. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for treating cancer comprising administration of the compounds of the invention.
Public/Granted literature
- US20080280899A1 Inhibitors of Akt Activity Public/Granted day:2008-11-13
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