An article of footwear is disclosed that includes a fluid-filled chamber with one or more flexion zones. The flexion zones may be areas of the chamber where a tensile element, for example, is absent, or the flexion zones may be areas of the chamber where opposite surfaces of the chamber are bonded together. The footwear may also include a sole structure with a flexion zone, and the flexion zone of the chamber may be aligned with the flexion zone of the sole structure. In other configurations, the chamber may include a chamber secured within a depression of a midsole of the footwear.