An occlusion valve with safety relief comprising a manifold block having an inlet and an outlet. A diaphragm connected to the manifold block and for being manually pressed to stop flow between the inlet and the outlet. A pressure relief valve internal to the manifold block and in fluid communication with downstream and upstream pressures and wherein when the diaphragm is pressed and downstream pressure exceeds a predetermined pressure the pressure relief valve opens allowing flow through the occlusion valve with safety relief.