An open roof construction for a vehicle having a roof opening defined in a stationary roof part includes a roof assembly having a movable panel for opening and closing said roof opening, with a slide which is movable along a stationary slide guide and which is provided with panel engagement device cooperating with a panel curve of the movable panel, wherein a movement of the slide is capable of generating a tilting and/or sliding movement of the panel. The roof assembly further includes a locking lever which by means of a hinge point is connected to the panel and which is provided with slide engagement device cooperating with a slide curve of the slide. A guide member cooperating with a stationary lever guide and a locking member cooperating with a stationary locking guide, such that in a first position of the slide the locking member is housed in a first stationary locking guide part preventing a translational movement of the locking lever and panel connected therewith and in a second position of the slide the locking member is housed in a second stationary locking guide part allowing a translational movement of the locking lever, and thus of the panel connected therewith at the hinge point.