A catheter is provided having anchoring and stabilizing devices adapted to respectively sit in and outside an opening of a tubular region. A sheath covering the catheter body forms the anchoring and stabilizing devices, which sheath comprises slits cut into the sheath creating spines. The spines are radially expanded by distal movement of the sheath relative to the catheter body. Radial expansion of the anchoring device generally anchors the distal end of the catheter inside the tubular region. Radial expansion of the stabilizing assembly generally stabilizes the distal end of the catheter against the ostium of the tubular region. The pressure exerted on the tubular region by the anchoring and stabilizing devices minimizes translational and rotational movement of the distal end of the catheter. Alternatively, the catheter may include a telescoping portion extending from the distal end of the catheter in which the anchoring and stabilizing devices are deployed by movement of a puller wire.