Invention Grant
- Patent Title: Method for treating cancer using a Notch4 ligand antagonist
- Patent Title (中): 使用Notch4配体拮抗剂治疗癌症的方法
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Application No.: US11607780Application Date: 2006-12-01
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Publication No.: US07754206B2Publication Date: 2010-07-13
- Inventor: Michael F. Clarke , Max S. Wicha , Muhammad Al-Hajj
- Applicant: Michael F. Clarke , Max S. Wicha , Muhammad Al-Hajj
- Applicant Address: US MI Ann Arbor
- Assignee: The Regents of the University of Michigan
- Current Assignee: The Regents of the University of Michigan
- Current Assignee Address: US MI Ann Arbor
- Agency: Casimir Jones SC
- Main IPC: A61K39/395
- IPC: A61K39/395 ; C07K16/18
Abstract:
The invention provides methods for treating cancer via administering to a patient having a solid tumor a therapeutically effective amount of an antibody against Delta-like ligand 4 (D114). The solid tumor may comprise solid tumor stem cells.
Public/Granted literature
- US20070231325A1 Prospective identification and characterization of breast cancer stem cells Public/Granted day:2007-10-04
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