Invention Grant
- Patent Title: Vaccines comprising aluminum adjuvants and histidine
- Patent Title (中): 包含铝佐剂和组氨酸的疫苗
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Application No.: US11968920Application Date: 2008-01-03
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Publication No.: US07754218B2Publication Date: 2010-07-13
- Inventor: Mario Contorni , Massimo Maffei
- Applicant: Mario Contorni , Massimo Maffei
- Applicant Address: IT Siena
- Assignee: Novartis Caccines and Diagnostics SRL
- Current Assignee: Novartis Caccines and Diagnostics SRL
- Current Assignee Address: IT Siena
- Agent Amy Hessler; Helen Lee; Robert Corman
- Priority: GB0118249.2 20010726; WOPCT/IB02/03191 20020620
- Main IPC: A61K39/02
- IPC: A61K39/02 ; A61K39/38 ; A61K39/116 ; C07K14/00
Abstract:
To improve the stability of vaccines comprising aluminum salt(s), the invention uses the amino acid histidine. This can improve pH stability and adjuvant adsorption and can reduce antigen hydrolysis. Histidine is preferably present during adsorption to the aluminum salt(s). The antigen in the vaccine may be a protein or a saccharide and is preferably from N. meningitidis.
Public/Granted literature
- US20080160045A1 Vaccines Comprising Aluminum Adjuvants and Histidine Public/Granted day:2008-07-03
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