Invention Grant
US07754227B2 Method of immunizing humans against Salmonella typhi using a Vi-rEPA conjugate vaccine
失效
使用Vi-rEPA结合疫苗免疫人类伤寒沙门氏菌的方法
- Patent Title: Method of immunizing humans against Salmonella typhi using a Vi-rEPA conjugate vaccine
- Patent Title (中): 使用Vi-rEPA结合疫苗免疫人类伤寒沙门氏菌的方法
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Application No.: US11726304Application Date: 2007-03-20
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Publication No.: US07754227B2Publication Date: 2010-07-13
- Inventor: Zuzana Kossaczka , Shousun Chen Szu , John B. Robbins , Rachel Schneerson , Joseph Shiloach
- Applicant: Zuzana Kossaczka , Shousun Chen Szu , John B. Robbins , Rachel Schneerson , Joseph Shiloach
- Applicant Address: US DC Washington
- Assignee: The United States of America as represented by the Department of Health and Human Services
- Current Assignee: The United States of America as represented by the Department of Health and Human Services
- Current Assignee Address: US DC Washington
- Agency: Klarquist Sparkman, LLP
- Main IPC: A61K39/112
- IPC: A61K39/112
Abstract:
This invention relates to conjugates of the Vi polysaccharide of S. typhi with the carrier Pseudomonas aeruginosa recombinant exoprotein A (rEPA), and compositions thereof, and to methods of using of these conjugates and/or compositions thereof for eliciting an immunogenic response in humans, including responses which provide protection against, or reduce the severity of, S. typhi bacterial infections. The conjugates, and compositions thereof, are useful as vaccines to induce serum antibodies against S. typhi and are useful to prevent and/or treat illnesses caused by S. typhi.
Public/Granted literature
- US20070172501A1 Method of immunizing humans against salmonella typhi using a Vi-rEPA conjugate vaccine Public/Granted day:2007-07-26
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