Invention Grant
- Patent Title: Macromonomer for preparation of a degradable hydrogel
- Patent Title (中): 用于制备可降解水凝胶的大分子单体
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Application No.: US11271405Application Date: 2005-11-10
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Publication No.: US07754241B1Publication Date: 2010-07-13
- Inventor: Charles K. Webb , Naren R. Vyavahare
- Applicant: Charles K. Webb , Naren R. Vyavahare
- Assignee: Clemson University Research Foundation
- Current Assignee: Clemson University Research Foundation
- Agency: Dority & Manning, P.A.
- Main IPC: A61K9/14
- IPC: A61K9/14 ; A61K9/00 ; C12N11/08 ; C12N11/04 ; C07K17/04 ; C07K17/08

Abstract:
A degradable hydrogel and a method of making a degradable hydrogel is disclosed herein. The method comprises obtaining a hydrophilic polymer having at least two hydroxyl groups, reacting the hydrophilic polymer with a di-functional monomer comprised of an acid halide group and an alkyl halide group to form an intermediate having an ester bond and a terminal alkyl halide group, reacting the terminal alkyl halide group of the intermediate with a metallic salt of a vinyl acid monomer to form a macromonomer comprised of an ester, an alkyl group spacer, and a terminal vinyl group, and polymerizing the macromonomer to form a degradable hydrogel. A method is also disclosed for varying the degradation rate of the hydrogel as a function of the chemical composition of the alkyl group spacer in the terminal linkage of the macromonomer.
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