Invention Grant
US07754423B2 Methods for predicting the risk of diabetic nephropathy using genetic markers and arrays containing the same 有权
使用遗传标记和含有其的阵列预测糖尿病肾病风险的方法

Methods for predicting the risk of diabetic nephropathy using genetic markers and arrays containing the same
Abstract:
Disclosed is a method for detecting a Chinese diabetic subject suffering from, at risk for developing, or suspected of suffering from a nephropathy. The method includes determining whether a sample from the subject has at least one polymorphic sequence selected from the group consisting of polymorphic sequences an I/D genotype of an ACE gene, an M235T genotype of an AGT gene, a (CA) n-5′ (z-2) genotype of an ALR2 gene, an C106T genotype of an ALR2 gene in the promoter region, a G-308A genotype of a TNF-α gene, and a complement thereof, provided that the ALR2 gene cannot be used alone, in which the presence of the polymorphic sequence indicates the subject suffering from, or at risk for suffering from a nephropathy. Also provided is an array for detecting a Chinese diabetic subject suffering from, or at risk for suffering from a nephropathy.
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