Invention Grant
- Patent Title: Methods for predicting the risk of diabetic nephropathy using genetic markers and arrays containing the same
- Patent Title (中): 使用遗传标记和含有其的阵列预测糖尿病肾病风险的方法
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Application No.: US10591824Application Date: 2005-04-15
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Publication No.: US07754423B2Publication Date: 2010-07-13
- Inventor: Juliana C. N. Chan , Maggie C. Y. Ng , Wing Yee So
- Applicant: Juliana C. N. Chan , Maggie C. Y. Ng , Wing Yee So
- Applicant Address: CN Hong Kong
- Assignee: The Chinese University of Hong Kong
- Current Assignee: The Chinese University of Hong Kong
- Current Assignee Address: CN Hong Kong
- Agency: Knobbe Martens Olson & Bear LLP
- Priority: CN200410033864 20040415
- International Application: PCT/CN2005/000508 WO 20050415
- International Announcement: WO2005/099335 WO 20051027
- Main IPC: C12Q1/68
- IPC: C12Q1/68 ; C12P19/34

Abstract:
Disclosed is a method for detecting a Chinese diabetic subject suffering from, at risk for developing, or suspected of suffering from a nephropathy. The method includes determining whether a sample from the subject has at least one polymorphic sequence selected from the group consisting of polymorphic sequences an I/D genotype of an ACE gene, an M235T genotype of an AGT gene, a (CA) n-5′ (z-2) genotype of an ALR2 gene, an C106T genotype of an ALR2 gene in the promoter region, a G-308A genotype of a TNF-α gene, and a complement thereof, provided that the ALR2 gene cannot be used alone, in which the presence of the polymorphic sequence indicates the subject suffering from, or at risk for suffering from a nephropathy. Also provided is an array for detecting a Chinese diabetic subject suffering from, or at risk for suffering from a nephropathy.
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