Invention Grant
US07754458B2 Crystal structure of the complex of hepatocyte growth factor beta chain with met receptor and methods of use
失效
肝细胞生长因子β链与受体受体的复合物的晶体结构和使用方法
- Patent Title: Crystal structure of the complex of hepatocyte growth factor beta chain with met receptor and methods of use
- Patent Title (中): 肝细胞生长因子β链与受体受体的复合物的晶体结构和使用方法
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Application No.: US12015993Application Date: 2008-01-17
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Publication No.: US07754458B2Publication Date: 2010-07-13
- Inventor: Christian Wiesmann , Jennifer Stamos
- Applicant: Christian Wiesmann , Jennifer Stamos
- Applicant Address: US CA South San Francisco
- Assignee: Genentech, Inc.
- Current Assignee: Genentech, Inc.
- Current Assignee Address: US CA South San Francisco
- Agency: Morrison & Foerster LLP
- Main IPC: C12N9/00
- IPC: C12N9/00 ; G01N31/00
Abstract:
The disclosure provides a crystal structure of a complex of the HGF β-chain with am extracellular fragment of the Met receptor, as well as use of the crystal structure in the design, identification, and selection of ligands that modulate the Met Receptor and the interaction of HGF with the Met receptor.
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