Invention Grant
US07754461B2 Large-scale production of human serum butyrylcholinesterase as a bioscavenger
失效
大规模生产人血清丁酰胆碱酯酶作为生物识别剂
- Patent Title: Large-scale production of human serum butyrylcholinesterase as a bioscavenger
- Patent Title (中): 大规模生产人血清丁酰胆碱酯酶作为生物识别剂
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Application No.: US11733246Application Date: 2007-04-10
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Publication No.: US07754461B2Publication Date: 2010-07-13
- Inventor: Bhupendra P. Doctor , Ashima Saxena , Wei Sun , Chunyuan Luo , Prasanthi Tipparaju , Irwin Koplovitz , David E. Lenz , Michelle C. Ross
- Applicant: Bhupendra P. Doctor , Ashima Saxena , Wei Sun , Chunyuan Luo , Prasanthi Tipparaju , Irwin Koplovitz , David E. Lenz , Michelle C. Ross
- Applicant Address: US DC Washington
- Assignee: The United States of America as represented by the Secretary of the Army
- Current Assignee: The United States of America as represented by the Secretary of the Army
- Current Assignee Address: US DC Washington
- Agent Elizabeth Arwine
- Main IPC: C12N9/16
- IPC: C12N9/16 ; C12N9/14 ; C12N9/00 ; A61K38/46
Abstract:
Disclosed herein are methods for the large-scale preparation of human butyrylcholinesterase (HuBChE) preparations from Cohn Fraction IV-4. As disclosed, the methods provide HuBChE preparations that are about 99% or more pure with recovery yields of about 60%. Also disclosed are the pharmacokinetics, safety and toxicity, stability and efficacy of the HuBChE preparations.
Public/Granted literature
- US20070184045A1 Large-Scale Production of Human Serum Butyrylcholinesterase as a Bioscavenger Public/Granted day:2007-08-09
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