Invention Grant
US07754690B2 Method of using retro inverso peptides derived from leukemia inhibitory factor
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使用衍生自白血病抑制因子的复发逆转肽的方法
- Patent Title: Method of using retro inverso peptides derived from leukemia inhibitory factor
- Patent Title (中): 使用衍生自白血病抑制因子的复发逆转肽的方法
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Application No.: US11501975Application Date: 2006-08-09
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Publication No.: US07754690B2Publication Date: 2010-07-13
- Inventor: David E. Wright , D. Elliott Parks
- Applicant: David E. Wright , D. Elliott Parks
- Applicant Address: US NJ Iselin
- Assignee: Myelos Corporation
- Current Assignee: Myelos Corporation
- Current Assignee Address: US NJ Iselin
- Agency: Kenyon & Kenyon LLP
- Main IPC: A61K38/16
- IPC: A61K38/16 ; C07K7/08
Abstract:
The invention provides methods of treatment using retro-inverso peptides derived from leukemia inhibitory factor (LIF) having between 18 and about 40 amino acids and including the sequence that is retro-inverso with respect to SEQ ID NO: 1. The peptides of the invention have the same activity as native LIF and also have neurotrophic activity. The peptides of the invention are also less susceptible to proteolytic degradation in vivo because of their D-amino acid linkage.
Public/Granted literature
- US20070049520A1 Method of using retro inverso peptides derived from leukemia inhibitory factor Public/Granted day:2007-03-01
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