Invention Grant
- Patent Title: Cycloalkane-containing sphingosine 1-phosphate agonists
- Patent Title (中): 含环烷烃的鞘氨醇1-磷酸激动剂
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Application No.: US11816258Application Date: 2006-02-14
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Publication No.: US07754703B2Publication Date: 2010-07-13
- Inventor: Kevin R. Lynch , Timothy L. Macdonald
- Applicant: Kevin R. Lynch , Timothy L. Macdonald
- Applicant Address: US VA Charlottseville
- Assignee: University of Virginia Patent Foundation
- Current Assignee: University of Virginia Patent Foundation
- Current Assignee Address: US VA Charlottseville
- Agency: Prout International IP, LLC
- International Application: PCT/US2006/005304 WO 20060214
- International Announcement: WO2006/088944 WO 20060824
- Main IPC: A61K31/661
- IPC: A61K31/661 ; A61K31/133 ; C07F9/09 ; C07C215/44
Abstract:
The present invention provides sphingosine-1-phosphate analogs that are potent, and selective agonists at one or more S1P receptors, specifically the S1P1 receptor type. The compounds invention include compounds having a phosphate moiety as well as compounds with hydrolysis-resistant phosphate surrogates such as phosphonates, alpha-substituted phosphonates, and phosphothionates.
Public/Granted literature
- US20080249070A1 Cycloalkane-Containing Sphingosine 1-Phospate Agonists Public/Granted day:2008-10-09
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