Invention Grant
US07754745B2 Azacyclopentane derivatives as inhibitors of stearoyl-coenzyme a delta-9 desaturase
失效
氮杂环戊烷衍生物作为硬脂酰辅酶抑制剂，δ-9去饱和酶
- Patent Title: Azacyclopentane derivatives as inhibitors of stearoyl-coenzyme a delta-9 desaturase
- Patent Title (中): 氮杂环戊烷衍生物作为硬脂酰辅酶抑制剂，δ-9去饱和酶
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Application No.: US12227549Application Date: 2007-06-08
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Publication No.: US07754745B2Publication Date: 2010-07-13
- Inventor: Chun Sing Li , Yeeman K. Ramtohul
- Applicant: Chun Sing Li , Yeeman K. Ramtohul
- Applicant Address: CA Quebec
- Assignee: Merck Frosst Canada Ltd.
- Current Assignee: Merck Frosst Canada Ltd.
- Current Assignee Address: CA Quebec
- Agent Philippe L. Derette; John C. Todaro
- International Application: PCT/CA2007/001027 WO 20070608
- International Announcement: WO2007/143824 WO 20071221
- Main IPC: C07D417/04
- IPC: C07D417/04 ; A61K31/433 ; A61K31/427
Abstract:
Azacyclopentane derivatives of structural formula (I) are selective inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD1) relative to other known stearoyl-coenzyme A desaturases. The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease; atherosclerosis; obesity; diabetes; neurological disease; metabolic syndrome; insulin resistance; liver steatosis; and non-alcoholic steatohepatitis.
Public/Granted literature
- US20090093527A1 Azacyclopentane Derivatives as Inhibitors of Stearoyl-Coenzyme a Delta-9 Desaturase Public/Granted day:2009-04-09
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