The present disclosure relates generally to systems and methods for transmitter leak-over cancellation. In one example, a method includes transmitting a signal via a transmit chain in a wireless device, where a portion of the signal leaks over into a receive chain of the wireless device and generates higher order products that interfere with a signal being received by the wireless device. A portion of the signal from the transmit chain is diverted into cancellation circuitry coupled to the receive chain prior to a location in the transmit chain where leak-over occurs, and an amplitude and phase of the portion is manipulated. The manipulated portion is combined with the received signal and other portion to at least partially cancel interference caused by the portion leaking over into the receive chain.