A system, apparatus and method for multithread handling on a multithread processing device are described herein. Embodiments of the present invention provide a multithread processing device for multithread handling including a plurality of registers operatively coupled to an instruction dispatch block, including thread-control registers for selectively disabling threads. In various embodiments, the multithread processing device may include a thread-operation register for selectively providing a lock to a first thread to prevent a second thread from disabling the first thread while the first thread has the lock. In still further embodiments, the multithread processing device may be configured to atomically disable and release a lock held by a thread. Other embodiments may be described and claimed.