Method of manufacturing resin particles capable of manufacturing resin particles of controlled particle size stably and efficiently by removing bubbles from the surface of a molten kneaded product as the raw material for resin particles thereby sufficiently ensuring action sites for a surfactant on the surface of the molten kneaded product, is provided. The method includes a coarsely-pulverizing step of pressurizing a mixture of a molten kneaded product containing a synthetic resin and an aqueous medium containing a surfactant to 15 MPa to 120 MPa thereby removing bubbles attached to the molten kneaded product containing the synthetic resin, and a finely-granulating step of finely granulating, by a high pressure homogenizer method, an aqueous slurry containing coarse particles of a molten kneaded product passing through a pressure proof nozzle in the coarsely-pulverizing step and in a state where bubbles attached to the surface are removed.