Invention Grant
- Patent Title: Use of synthetic glycolipids as universal adjuvants for vaccines against cancer and infectious diseases
- Patent Title (中): 使用合成糖脂作为抗癌和传染病疫苗的通用佐剂
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Application No.: US10962374Application Date: 2004-10-08
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Publication No.: US07771726B2Publication Date: 2010-08-10
- Inventor: Moriya Tsuji , John Schmieg , Richard Franck , Yaoxing Huang
- Applicant: Moriya Tsuji , John Schmieg , Richard Franck , Yaoxing Huang
- Applicant Address: US NY New York US NY New York US NY New York
- Assignee: New York University,The Research Foundation of the City University of New York,Aaron Diamond Aids Research Center
- Current Assignee: New York University,The Research Foundation of the City University of New York,Aaron Diamond Aids Research Center
- Current Assignee Address: US NY New York US NY New York US NY New York
- Agency: Fish & Richardson P.C.
- Main IPC: A61K39/39
- IPC: A61K39/39
Abstract:
The present invention relates to methods and compositions for augmenting an immunogenicity of an antigen in a mammal, comprising administering said antigen together with an adjuvant composition that includes a synthetic glycolipid compound of Formula I, as described herein. According to the present invention, the use of a compound of Formula I as an adjuvant is attributed at least in part to the enhancement and/or extension of antigen-specific Th1-type responses, in particular, CD8+ T cell responses. The methods and compositions of the present invention can be useful for prophylaxis and treatment of various infectious and neoplastic diseases.
Public/Granted literature
- US20050192248A1 Use of synthetic glycolipids as universal adjuvants for vaccines against cancer and infectious diseases Public/Granted day:2005-09-01
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