Invention Grant
US07771729B2 Methods of potentiating HIV-1-specific CD8+ immune responses involving the concomitant administration of DNA and ALVAC expression vectors
有权
增强HIV-1特异性CD8 +免疫反应的方法，涉及DNA和ALVAC表达载体的同时施用
- Patent Title: Methods of potentiating HIV-1-specific CD8+ immune responses involving the concomitant administration of DNA and ALVAC expression vectors
- Patent Title (中): 增强HIV-1特异性CD8 +免疫反应的方法，涉及DNA和ALVAC表达载体的同时施用
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Application No.: US11428815Application Date: 2006-07-05
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Publication No.: US07771729B2Publication Date: 2010-08-10
- Inventor: Genoveffa Franchini , Zdenek Hel , George Pavlakis , James Tartaglia
- Applicant: Genoveffa Franchini , Zdenek Hel , George Pavlakis , James Tartaglia
- Applicant Address: US DC Washington
- Assignee: The United States of America as represented by the Department of Health and Human Services
- Current Assignee: The United States of America as represented by the Department of Health and Human Services
- Current Assignee Address: US DC Washington
- Agency: Sheridan Ross PC
- Main IPC: A61K39/12
- IPC: A61K39/12 ; A61K39/21 ; A61K39/275 ; C07H21/04 ; C12N7/04
Abstract:
This invention relates to improved methods of inducing an immune response for the prevention or treatment of HIV-1 infection by using a nucleic acid vaccine in conjunction with a recombinant viral vaccine, e.g., a poxvirus vaccine, to potentiate and broaden the immune response. The present invention further provides a particularly effective vaccine regimen comprising a DNA vaccine used in combination with a poxvirus virus, especially NYVAC or ALVAC.
Public/Granted literature
- US20060240042A1 IMMUNOGENICITY USING A COMBINATION OF DNA AND VACCINIA VIRUS VECTOR VACCINES Public/Granted day:2006-10-26
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