Invention Grant
US07771746B2 Methods for making sustained-release pharmaceutical compositions of ergot alkaloids having improved bioavailability and compositions thereof
有权
制备具有改善的生物利用度的麦角生物碱的持续释放药物组合物的方法及其组合物
- Patent Title: Methods for making sustained-release pharmaceutical compositions of ergot alkaloids having improved bioavailability and compositions thereof
- Patent Title (中): 制备具有改善的生物利用度的麦角生物碱的持续释放药物组合物的方法及其组合物
-
Application No.: US10992114Application Date: 2004-11-19
-
Publication No.: US07771746B2Publication Date: 2010-08-10
- Inventor: Federico Mailland
- Applicant: Federico Mailland
- Applicant Address: LU Val Fleuri
- Assignee: Polichem SA
- Current Assignee: Polichem SA
- Current Assignee Address: LU Val Fleuri
- Agency: Nixon & Vanderhye
- Main IPC: A61K9/20
- IPC: A61K9/20 ; A61K9/22
Abstract:
A method of improving bioavailability of ergot derivatives administered using sustained-release delivery systems includes combining an ergot derivative or mixture thereof with a pharmaceutically acceptable hydrophilic swelling agent or mixture thereof and one or more pharmaceutically acceptable excipients. The bioavailability of sustained-release formulations of the present invention is at least equal to the bioavailability of the ergot derivative or mixture thereof administered using a conventional delivery system. Sustained-release compositions that improve bioavailability are also provided. Methods and compositions according to the present invention may provide sustained-release characteristics while improving the bioavailability of ergot derivatives.
Public/Granted literature
Information query
