Invention Grant
- Patent Title: CD10-activated prodrug compounds
- Patent Title (中): CD10活化前药化合物
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Application No.: US11986096Application Date: 2007-11-20
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Publication No.: US07771962B2Publication Date: 2010-08-10
- Inventor: Christopher R. Bebbington , Matthew H. Nieder , Pina M. Cardarelli , Sanjeev Gangwar , Lesley B. Pickford , Chin Pan
- Applicant: Christopher R. Bebbington , Matthew H. Nieder , Pina M. Cardarelli , Sanjeev Gangwar , Lesley B. Pickford , Chin Pan
- Applicant Address: US NJ Princeton
- Assignee: Medarex, Inc.
- Current Assignee: Medarex, Inc.
- Current Assignee Address: US NJ Princeton
- Agency: Lahive & Cockfield, LLP
- Agent Jane E. Remillard; Brian C. Trinque
- Main IPC: C12Q1/37
- IPC: C12Q1/37
Abstract:
The compounds of the invention are modified forms of therapeutic agents. A typical prodrug compound of the invention comprises a therapeutic agent, an oligopeptide, a stabilizing group and, optionally, a linker group. The prodrug is cleavable by the CD10 enzyme. Methods of treatment using the prodrug and methods of designing the prodrug are also disclosed.
Public/Granted literature
- US20090136980A1 CD10-activated prodrug compounds Public/Granted day:2009-05-28
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