Invention Grant
US07772218B2 Synthesis of anti-estrogenic and other therapeutic steroids from 21-hydroxy-19-norpregna-4-en-3-one
有权
从21-羟基-19-去甲孕烯-4-烯-3-酮合成抗雌激素和其它治疗类固醇
- Patent Title: Synthesis of anti-estrogenic and other therapeutic steroids from 21-hydroxy-19-norpregna-4-en-3-one
- Patent Title (中): 从21-羟基-19-去甲孕烯-4-烯-3-酮合成抗雌激素和其它治疗类固醇
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Application No.: US10915302Application Date: 2004-08-09
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Publication No.: US07772218B2Publication Date: 2010-08-10
- Inventor: Richard H. Peters , Jyanwei Liu , John G. Johansson , Kenneth J. Ryan , Wan-Ru Chao , Masato Tanabe
- Applicant: Richard H. Peters , Jyanwei Liu , John G. Johansson , Kenneth J. Ryan , Wan-Ru Chao , Masato Tanabe
- Applicant Address: US CA Menlo Park
- Assignee: SRI International
- Current Assignee: SRI International
- Current Assignee Address: US CA Menlo Park
- Agency: Bozicevic, Field & Francis LLP
- Agent Isaac M. Rutenberg
- Main IPC: C07J41/00
- IPC: C07J41/00 ; C07J43/00
Abstract:
Syntheses of steroids such as 3-hydroxy-7α-methyl-21-[2′-methoxy-4′-(diethylaminomethyl)-phenoxy]-19-norpregna-1,3,5(10)triene citrate (“SR 16234”) and analogs thereof are provided, wherein 21-hydroxy-19-norpregna-4-en-3-one serves as a starting material or intermediate. The latter compound may be readily prepared from estrone-3-methyl ether. Certain intermediates in these syntheses also have value as therapeutic agents, for example in the treatment of prostate disorders such as prostatic cancer.
Public/Granted literature
- US20050009801A1 Synthesis of anti-estrogenic and other therapeutic steroids from 21-hydroxy-19-norpregna-4-en-3-one Public/Granted day:2005-01-13
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