Invention Grant
- Patent Title: Variolin derivatives and their use as antitumor agents
- Patent Title (中): 异喹啉衍生物及其作为抗肿瘤剂的用途
-
Application No.: US12349813Application Date: 2009-01-07
-
Publication No.: US07772241B2Publication Date: 2010-08-10
- Inventor: Modesto Remuinan , Juan Jose Gonzalez , Carlos Del Pozo , Andres Francesh , Carmen Cuevas , Simon Munt , Ignacio Manzanares , Regan James Anderson , Jonathan Charles Morris
- Applicant: Modesto Remuinan , Juan Jose Gonzalez , Carlos Del Pozo , Andres Francesh , Carmen Cuevas , Simon Munt , Ignacio Manzanares , Regan James Anderson , Jonathan Charles Morris
- Applicant Address: ES Madrid
- Assignee: Pharma Mar S.A.
- Current Assignee: Pharma Mar S.A.
- Current Assignee Address: ES Madrid
- Agency: King & Spalding LLP
- Agent Kenneth H. Sonnenfeld
- Priority: GB0116966.3 20010711
- Main IPC: A61K31/519
- IPC: A61K31/519 ; C07D473/00
Abstract:
Variolin derivatives of formula (5) are provided, wherein the substituent groups defined by X2, R1, R2, R3, R6, R7, and R12 are each independently selected from the group consisting of H, OH, OR′, SH, SR′, SOR′, SO2R′, NO2, NH2, NHR′, N(R′)2, NHCOR′, NHSO2R′, CN, halogen, ═O, C(═O)H, C(═O)R′, CO2H, CO2R′, carboxyalkyl, C1-C12 alkyl, C2-C12 alkenyl, C2-C12 alkynyl, substituted or unsubstituted aryl, substituted or unsubstituted aralkyl and substituted or unsubstituted heteroaromatic; wherein each of the R′ groups is independently selected from the group consisting of H, OH, SH, NO2, NH2, CN, halogen, ═O, C(═O)H, C(═O)CH3, CO2H, CO2CH3, C1-C12 alkyl, C2-C12 alkenyl, C2-C12 alkynyl, aryl, aralkyl and heteroaromatic; wherein the pairs of groups of R1 and R2, R2 and R3, R3 and R12, R12 and R6, or R6 and R7 may be joined into a carbocyclic or heterocyclic ring system.
Public/Granted literature
- US20090197901A1 VARIOLIN DERIVATIVES AND THEIR USE AS ANTITUMOR AGENTS Public/Granted day:2009-08-06
Information query
IPC分类:
