Invention Grant
- Patent Title: Substituted benzoylguanidines, method for production and use thereof as medicament or diagnostic and medicament comprising the same
- Patent Title (中): 取代的苯甲酰胍，其制备方法及其用作药物或诊断剂及包含其的药物
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Application No.: US11748166Application Date: 2007-05-14
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Publication No.: US07772262B2Publication Date: 2010-08-10
- Inventor: Heinz-Werner Kleemann
- Applicant: Heinz-Werner Kleemann
- Applicant Address: DE Frankfurt am Main
- Assignee: sanofi-aventis Deutschland GmbH
- Current Assignee: sanofi-aventis Deutschland GmbH
- Current Assignee Address: DE Frankfurt am Main
- Agent James W. Bolcsak
- Priority: DE102004054847 20041113
- Main IPC: C07D285/16
- IPC: C07D285/16 ; C07D275/02 ; A61K31/54
Abstract:
The present invention relates to substituted benzoylguanidines of the formula I: in which R1 to R8 and X and Y are as described in the specification, and their pharmaceutically acceptable salts are substituted acylguanidines as inhibitors of the cellular sodium-proton antiporter (Na+/H+ exchanger, NHE).
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