Invention Grant
- Patent Title: Two helix binders
- Patent Title (中): 两个螺旋粘合剂
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Application No.: US12337941Application Date: 2008-12-18
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Publication No.: US07772363B2Publication Date: 2010-08-10
- Inventor: Rong Zhang , Faisal Ahmed Syud , Jack Mathew Webster
- Applicant: Rong Zhang , Faisal Ahmed Syud , Jack Mathew Webster
- Applicant Address: US NY Niskayuna
- Assignee: General Electric Company
- Current Assignee: General Electric Company
- Current Assignee Address: US NY Niskayuna
- Agent Jennifer E. Haeckl
- Main IPC: G01N33/566
- IPC: G01N33/566 ; C07K14/00 ; C07K5/10
Abstract:
An isolated polypeptide, Z domain, derived from B domain of Staphylococcal protein A, comprising a pair of anti-parallel alpha helices that are capable of binding a target, is provided herein. Introduction of an engineered disulfide bridge between two natural or un-natural amino acids in the polypeptide is provided here. Also provided are methods of using the two-helix binders.
Public/Granted literature
- US20100035361A1 TWO HELIX BINDERS Public/Granted day:2010-02-11
Information query
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