Invention Grant
US07772368B2 Deletion forms of IGE-dependent histamine releasing factor having histamine releasing activity, HRF-binding peptides and the uses thereof
有权
具有组胺释放活性的IGE依赖性组胺释放因子的缺失形式，HRF结合肽及其用途
- Patent Title: Deletion forms of IGE-dependent histamine releasing factor having histamine releasing activity, HRF-binding peptides and the uses thereof
- Patent Title (中): 具有组胺释放活性的IGE依赖性组胺释放因子的缺失形式，HRF结合肽及其用途
-
Application No.: US11307141Application Date: 2006-01-25
-
Publication No.: US07772368B2Publication Date: 2010-08-10
- Inventor: Kyunglim Lee , Miyoung Kim
- Applicant: Kyunglim Lee , Miyoung Kim
- Applicant Address: KR Seoul
- Assignee: Ewha University-Industry Collaboration Foundation
- Current Assignee: Ewha University-Industry Collaboration Foundation
- Current Assignee Address: KR Seoul
- Agency: JHK Law
- Agent Joseph Hyosuk Kim
- Priority: KR10-2005-0006712 20050125
- Main IPC: C07K1/00
- IPC: C07K1/00
Abstract:
The present invention relates to IgE-dependent histamine releasing factor (HRF) and HRF-binding peptides, more precisely, deletion forms of HRF which are able to be formed as dimers containing amino acid sequence represented by SEQ ID NO:3, genes encoding thereof and novel HRF-binding peptides having an activity of inhibiting HRF. The deletion forms of HRF which are able to be formed as dimers of the present invention induces intracellular secretion of histamine and IL-8, making an excellent candidate for a drug for inhibiting allergic reaction triggered by HRF and a kit for detecting HRF in serum of an allergy patient. In addition, novel HFR-binding peptides of the present invention bind to HRF to inhibit the actions of HFR, so they can be effectively used for the prevention and the treatment of allergic diseases of animals including asthma and rhinitis or malaria.
Public/Granted literature
Information query
