Invention Grant
- Patent Title: Process for the preparation of lercanidipine
- Patent Title (中): 氯卡地平的制备方法
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Application No.: US12603896Application Date: 2009-10-22
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Publication No.: US07772401B2Publication Date: 2010-08-10
- Inventor: Bandi Parthasaradhi Reddy , Kura Rathnakar Reddy , Rapolu Raji Reddy , Dasari Muralidhara Reddy , Dandamudi Satish Kumar
- Applicant: Bandi Parthasaradhi Reddy , Kura Rathnakar Reddy , Rapolu Raji Reddy , Dasari Muralidhara Reddy , Dandamudi Satish Kumar
- Applicant Address: IN Hyderabad
- Assignee: Hetero Drugs Limited
- Current Assignee: Hetero Drugs Limited
- Current Assignee Address: IN Hyderabad
- Agency: Caesar, Rivise, Bernstein, Cohen & Pokotilow, Ltd.
- Main IPC: C07D213/26
- IPC: C07D213/26 ; C07C213/28

Abstract:
The invention provides a novel process for the preparation of lercanidipine or a pharmaceutical acceptable salt using novel intermediates. Thus, 2,N-dimethyl-N-(3,3-diphenylpropy1)-1-amino-2-propanol is reacted with trimethylsilyl chloride in presence of triethyl amine in methylene chloride to give 2,N-dimethyl-2-(trimethylsilyloxy)-N-(3,3-diphenylpropy1)-1-propanamine, which is then reacted with 2,6-dimethyl-5-methoxycarbonyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carbonyl chloride for 2 hours and crystallized to obtain lercanidipine hydrochloride.
Public/Granted literature
- US20100087653A1 NOVEL PROCESS FOR THE PREPARATION OF LERCANIDIPINE Public/Granted day:2010-04-08
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