Invention Grant
- Patent Title: Process of making sertraline form II
- Patent Title (中): 制备舍曲林II的方法
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Application No.: US12372103Application Date: 2009-02-17
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Publication No.: US07772437B2Publication Date: 2010-08-10
- Inventor: Bandi Parthasaradhi Reddy , Kura Rathnakar Reddy , Rapolu Raji Reddy , Dasari Muralidhara Reddy , Kesireddy Subash Chander Reddy
- Applicant: Bandi Parthasaradhi Reddy , Kura Rathnakar Reddy , Rapolu Raji Reddy , Dasari Muralidhara Reddy , Kesireddy Subash Chander Reddy
- Applicant Address: IN Hyderabad
- Assignee: Hetero Drugs Limited
- Current Assignee: Hetero Drugs Limited
- Current Assignee Address: IN Hyderabad
- Agency: Caesar, Rivise, Bernstein, Cohen & Pokotilow, Ltd.
- Main IPC: C07C209/00
- IPC: C07C209/00 ; C07C211/00
Abstract:
The present invention discloses novel and improved processes for preparation of sertraline hydrochloride crystalline form II. Thus, for example, sertraline free base is dissolved in isoamyl alcohol at 25-30° C., pH of the mass is adjusted to 2.0 with conc. hydrochloric acid (36%) at 25-30° C. and then stirred for 14 hours at 25-30° C. Filtered the solid and dried at 65° C. for 4 hours to give sertraline hydrochloride crystalline form II. The present invention also provides a novel process for preparation of sertraline hydrochloride crystalline form I.
Public/Granted literature
- US20090177009A1 PROCESS OF MAKING SERTRALINE FORM II Public/Granted day:2009-07-09
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