A slide mechanism (100) used in portable electronic device (300) is described including a main plate (10), a slide plate (20), two sliders (40), and two guiders (30). The slide plate is installed on the main plate and slidable relative to the main plate. The sliders are securely attached to the slide plate, and the guiders are securely attached to the main plate deformably guiding the sliders to move along it. When the slide plate slides along the main plate, the sliders and the guiders compress with each other, thereby generating deformations therebetween and driving the sliding of the slide plate along the main plate.