An AC/DC power supply with over-voltage protection includes a voltage converting circuit and a digital latch control circuit. The voltage converting circuit has a first-side winding, a second-side winding, and an auxiliary winding for providing a supply voltage according to the AC input voltage. The digital latch control circuit is coupled to the voltage converting circuit and utilized for latching a voltage level of the supply voltage at a first predetermined level according to an over-voltage protection (OVP) trigger signal, where the voltage converting circuit is disabled when the voltage level is latched at the first predetermined level.