The invention relates to a multi-transmission/reception antenna device and a multi-transmission/reception method in a multi-user and multi-cell environment. When a plurality of spatial subchannels having a multi-user and a multi-transmission/reception antenna are allocated to users (that is, user terminals), a user group to be supported and the number of users are selected in consideration of an influence of interference signals from adjacent cells. Accordingly, variability and independence of channels for users and interference signals from adjacent cells can be effectively used, thereby improving a transfer rate of a wireless communication system. The invention allows data transfer at higher speed with limited wireless resources. In particular, an influence of interference from adjacent cells that is inevitable in a multi-cell environment primarily used for the efficient use of wireless resources can be removed using a multi-transmission/reception antenna, while a transfer rate of each user can be effectively increased.