Provided are a method, system, and program for handling a fabric failure. A module intercepts a signal indicating a failure of a path in a fabric providing a connection to a shared device. The module generates an interrupt to a device driver in an operating system providing an interface to the shared device that is inaccessible due to the path failure. The device driver requests information from the module on a status of a plurality of devices that are not accessible due to the path failure and receives information indicating the inaccessible device. The device driver reconfigures to discontinue use of the inaccessible device.